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Chronic Fatigue Syndrome

Chronic Fatigue Syndrome


Chronic fatigue syndrome is defined as intense exhaustion for 6 months or more. Some people find they can’t function without chemical stimuli like coffee or stronger stimuli, although the benefits eventually wear off and their suffering continues. It is often associated with these common symptoms: 

sleeping, headaches, brain fog, mood swings, allergies, joint pain, sore throat and memory issues.

Chronic fatigue syndrome is defined as intense exhaustion for 6 months or more. Some people find they can’t function without chemical stimuli like coffee or stronger stimuli, although the benefits eventually wear off and their suffering continues. It is often associated with these common symptoms: 

Although doctors are unclear on the causes, there have been two common hypotheses about the underlying reasons for chronic fatigue syndrome.

  1. Adrenal Fatigue – Cortisol level cycle and constant high stress creates a situation where the hypothalamic-pituitary-adrenal axis (HPA axis) produces cortisol “stress hormone” all day.
  2. Leaky Gut contributing to NAFLD (non-alcohol fatty liver disease)


Leaky Gut

When the increase in harmful bacteria and yeast (candida) within the intestine reaches a tipping point, the intestinal wall is breached. This is in part caused by the aldehydes released when candida are in such high concentrations that they stand in competition with each other. The aldehydes that are secreted to ward each other off, breakdown the soft tissue holding our intestinal cells together called "desmosomes". This subsequent breach allows food particles to pass through the intestine wall and the immune system becomes overwhelmed. The liver, which receives 70% of its blood flow from the intestine, is charged with detoxify the blood.

If the necessary compounds for gluthione replenishment, methylation, acetylation are are in short supply the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body.3 These fat cells are stored in the liver and elsewhere throughout the body. This was the reason we developed Hepatiben, which contains the ingredients that can perform these activities and support proper liver function under these conditions.

In addition to finding a good natural supplement, find ways to alleviate stress and adjust your diet. Studies show that reducing stress and taking an adrenal support supplement in this regimen significantly speeds up recovery.


Metabolic Syndrome

METABOLIC SYNDROME


Having Metabolic Syndrome doubles the risk for heart disease and multiples the risk of diabetes by five.It is not a disease itself but describes a host of related risk factors (high blood pressure, high blood sugar, unhealthy cholesterol levels, obesity and insulin resistance) all with a common cause originally coined 20 years ago effecting 47 million Americans affected.

Notice that Metabolic Syndrome closely mirrors the symptoms found in those suffering from NAFLD . NAFLD can be thought of as the liver’s state of Metabolic Syndrome. Following the progression of Metabolic Syndrome and NAFLD, one has a hard time disputing the causal relationship.

Cause & Effect

We need to begin with the American diet, which has changed significantly over the past fifty plus years. Americans now consume far too much of the following:

“sugar, caffeine, harmful fats, antibiotics,
preservatives, pesticides, GMOs and hormones.”

These are all considered toxins to your body, especially sugar. In fact, the sugar is the major reason for the build-up of candida, which displaces the good bacteria. Why are we discussing the digestive tract? What does that have to do with obesity? Everything.

The digestive tract has a very complex function; it simultaneously does two operations.

  1. Create specific enzymes to breakdown digested food into smaller particles used in the body.
  2. Selectively allow nutrients through without passing the harmful invaders; virus, bacteria and toxins.

Our digestive tract is not alone in this work; it has between 3-5 lbs of bacteria in the gut to help. However, our new American diet promotes rapid growth of harmful bacteria.

Leaky Gut

When an increase in harmful bacteria and yeast (candida) within the intestine reaches a tipping point, the intestinal wall is breached. This breach allows food particles to pass through the intestine wall and the immune system becomes overwhelmed. The liver, which receives 70% of its blood flow from the intestine, is charged with detoxify the blood. If the necessary chemicals (i.e. Glutathione, NAC, Tocotrienols) are in short supply the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body.These fat cells are stored in the liver and elsewhere throughout the body. 2

“The liver receives 70% of its
blood flow from the intestine”

This fat cell build-up stored in the liver and elsewhere around the body, is producing an obesity epidemic.

Excess accumulation of fat cells in the liver begins a destructive cycle where the liver becomes less efficient, leading to a build-up of toxins including fatty acids and insulin. This spike in oxidative stress and unprocessed insulin leads to insulin resistance in type II diabetes. Tests confirm the overload of fatty acids called lipotoxicity. This cascade explains the risk factors relating to Metabolic Syndrome.

What Works

Fortunately nature provides us with the solution. Studies have shown Silybin (an active compound in milk thistle), SAMe, Vitamin E (specifically highly concentrated tocotrienols), NAC, Phosphatidylcholine and Glutathione to work best with repeatable results. The success of these natural ingredients relies on rapid replenishment of Glutathione, a critically important liver antioxidant.

Extracts from milk thistle have a long history of being used for liver protection. We are just now starting to rediscover this through scientific discovery. One very effective combination including; Silymarin, Vitamin E and Phosphatidylcholine improves insulin sensitivity, while reversing liver cell damage. This is accomplished by reducing oxidative stress and improving Glutathione levels in the liver.

N-acetyl cysteine (NAC) is a sulfur-rich compound used primarily to neutralize the damaging effects of aspirin on the liver. It rapidly restores Glutathione. A recent animal study showed it to prevent NAFLD in a liver disease diet. Similarly, SAMe had been found to increase Glutathione levels in humans with Non-Alcohol Fatty Liver Disease.

Very few if any products on the market today contain all these ingredients and they are very expensive when purchased individually. To address this Liver Medic formulated a more complete liver detox supplement to make fighting this battle easier, more effective and less expensive than the alternatives.

While we have discussed the mechanism and treatment for the liver, we can’t ignore the source of the problem. A healthy diet promotes a healthy gut, this is critically important to ensuring that fatty liver disease does not return.

Often missed in attempts to return to a healthy gut balance is the removal of candida and biofilm, a major obstacle in improving gut health. We have addressed this with other gut support products specifically formulated for candida removal and biofilm removal. Take these along with power liver supplements and the body will begin to regulate itself without the toxic interference.

The proper use of these products not only reverses liver damage but also protects against future damage.*


References

  1. http://www.webmd.com/heart/metabolic-syndrome/metabolic-syndrome-what-is-it
  2. http://obesity.bodyecology.com/leaky-gu
  3. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. Journal of Nutrition. 2009 Jan;139(1):63-
  4. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biological Chemistry. 2010 Jun 11;285(24):18528-
  5. Loguercio C, Federico A, Trappoliere M, et al. The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a pilot study. Digestive Disease & Sciences. 2007 Sep;52(9):2387-95.
  6. Serviddio G, Bellanti F, Giudetti AM, et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. Journal of Pharmacology and Experimental Therapeutics. 2010 Mar;332(3):922-32.
  7. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. Journal of Nutrition. 2008 Oct;138(10):1872-9.
  8. Vendemiale G, Altomare E, Trizio T, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand Journal of Gastroenterology. 1989 May;24(4):407-15.
Read More

Food Allergies


Food Allergies: Origins & Treatments


A food allergy is an abnormal reaction to food that triggers an immune response. In more severe cases such as Multiple Chemical Sensitivities (MCS) the body can’t defend itself and differs from a simple allergy. MCS affects over sixteen percent of Americans. 1

Food allergies often take place after a reduction of "friendly" bacteria in our gut's microbiome that allow pathogenic organisms to move in, which initiates leaky gut. Particially digested foods accompany virus, bacteria and other organisms that now stream past the gut lining non-selectively. This process stimulates our immune system and identify foods we are commonly eating as problematic. Our immune system will mount a counter attack and create what we call a food allergy. 

The liver also has a role to play in all this. Suffering from leaky gut, the liver is often in a state of over capacity and can no longer function effectively to perform acts like reducing toxins in the body. The increase in free floating toxins exacerbates an immune response already on high alert in an effort to protect itself from foreign particles from the gut. [See: Leaky Gut]

Treatment

Removing all toxins from the environment is the first step in recovery. This includes all toxins from meals containing pesticides, GMOs, molds and fungi. Also, take a look at personal care products including; shampoos, soaps, deodorants, perfumes, lotions and makeup. Many of these contain endocrine disrupting chemicals reviewed in a separate article. Secondly, the sleep environment must be cleared of mold, dust mites and mattresses treated with flame retardant chemicals. Investing in a HEPA filter would further improve air quality.

The causes of more severe cases are usually two-fold; liver toxicity and an imbalance of intestinal flora. The compounds in Hepatiben suport liver health and reductions in free floating toxins. Bringing the gut back into balance requires a reduction in opportunistic organisms like candida and biofilm, which can serve to protect deleterious organisms from our IgA (immune system compounds on the lumen side of our digestive tract. We recommend using a strong enzyme like Serrapeptase, to breakup biofilm and incorporating Candida Complex, is a great way to support candida rebalancing and reduction of GI tract parasites. More severe cases of leaky gut also benefit from repair ingredients of Leaky Gut Repair, so the soft tissue can recover. This will enable a surface that friendly bacteria can then bond to and flourish.


High Cholesterol

High Cholesterol & Chronic Inflammation


Chronic Inflammation is the true enemy, although the depth of this danger has only recently come to light in the last decade or so. It is the source of many health issues that are trending up in the past 50 years. It is difficult to find accurate statics on chronic inflammation, but it causes cardiovascular diseases and a host of other health issues.

Cholesterol, Chronic Inflammation Connection

When suffering from chronic inflammation, the body is literally under attack and produces cholesterol in greater amounts to help mend damaged tissue often in places such as blood vessels and arteries. It was thought that Cholesterol was the source of the problem, now we know it was the body’s defense against damage due to inflammation.

Causes of Chronic Inflammation

Listed below in order of importance are the drivers for chronic inflammation:

  1. Sugar
  2. Fatty Liver Disease
  3. Leaky Gut (Discussed in Obesity post)
  4. Stress
  5. Imbalance of Omegas 3 & 6 fatty acids
  6. Lack of sleep
  7. Poor Diet 

including: caffeine, alcohol, nicotine, processed carbs, antibiotics, GMOs, pesticides. Often giving rise to leaky gut, which can lead to NAFLD.

Poor diet cannot be overstated as a driver of chronic inflammation and within this category; sugar is one of the worst offenders. Free floating sugar in and of itself creates inflammation and makes the body chemistry acidic in addition to a myriad of other issues such as obesity, diabetes and heart disease.

A balance between Omega 3 and Omega 6 fatty acids is essential; when Omega 6 outnumbers Omega 3 the result may cause the body’s organs to become inflamed. Unfortunately, Americans consume 15 times more Omega 6 than Omega 3 fatty acids.

Fatty Liver Disease is often silent in the early stages, and those with high cholesterol may suffer while the disease goes undiagnosed and untreated. Any discussion regarding interrelated health issues should include liver disease or NAFLD in its many forms.

It’s important to note, that high cholesterol isn’t always associated with NAFLD or other more severe fatty liver diseases, but it often occurs in people with Type II Diabetes. The liver is the organ that keeps toxins safely neutralized and away from the rest of the body when functioning correctly.

With chronic inflammation, the liver most likely is inefficient or not working correctly. In addition to or as a result of inflammation, the body can suffer from hepatic lipotoxicity. This is found in NAFLD when the liver is overwhelmed by fatty acids and other toxins beyond its capacity to neutralize them.

For those not suffering from NAFLD, simple exercise and changes in diet can make a dramatic improvement. It’s vital to avoid all saturated and trans fats from the diet, but do not make the mistake of cutting fats. Some fats are very important to good health such as those found in fish oils, nuts, olive oil, coconut oil, and avocados to name a few.


The Fatty Liver, Leaky Gut Connection

The Fatty Liver, Leaky Gut Connection


Leaky Gut occurs when an increase in harmful bacteria and commonly yeast (candida) within the intestine reaches a tipping point and the intestinal wall is breached. These bacteria and candida can literally burrow between the cells of the intestinal lining like a root system. Most of the time, we have a symbiotic relationship with intestinal bacteria from birth and they help reduce harmful effects of toxins, breakdown food and aid in immune function. As a matter of fact intestinal bacteria outnumber the cells in our body ten-to-one.

But harmful bacteria can do the opposite and often this is exactly what takes place after a round of antibiotics. It can also occur after a severe cold but more typically Americans get it from their diets over longer periods of time.

If you are eating a consistently poor diet with excessive sugar like most of the 300 Million people in America, you may well be on your way to having a Leaky Gut too.

Leaky Gut is commonly caused by:

  1. Years of eating diets high in sugars, this can increase candida populations.
  2. Poor diet also increase bacteria colonies that are detrimental to good gut health.
  3. Use of antibiotics without immediate good bacteria reintroduction.
  4. Pesticides, GMOs and other harmful toxins that ravage the intestine walls and beneficial bacteria.

When our intestinal wall is breached, this allows food particles to pass through and over time the immune system becomes overwhelmed with invaders. As if this is not bad enough, your immune system may also attack its own cells near the intestinal wall openings as a sort of collateral damage. This heightened immune state is often associated with chronic inflammation of other parts of the body like the back.

Over time, the increasing influx of food particles charging through is too much and they must be processed some other way. The liver, which receives 70% of its blood flow from the intestine, is then charged with capturing and detoxifying the blood at this point.

If the necessary chemicals (i.e. Glutathione, NAC, Tocotrienols) are in short supply, the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body. These fat cells are stored in the liver and elsewhere throughout the body. This leads to obesity; cripples liver function and can be seen in higher than normal blood sugar levels, as the liver is critical in regulating insulin.

This is really the only option available to the liver at this point as it would be more dangerous to have these toxins floating in the blood disrupting other processes around the body.

The best way to counter this cycle is finding ways to alleviate stress, changing your diet and supplementing it with probiotics and strong liver anti-oxidants.

Fatty Liver & Leaky Gut Supplements To Consider

Milk thistle is often used, but many people aren’t aware that the bioavailability is 10 times higher when taking the isolated active in milk thistle (slybin). People that have fatty liver should also be taking NAC, SAMe, Turmeric and Glutathione. These are the top ingredients to reverse liver damage. All these seem to act in a way that kick starts phase II detoxification in the liver, which transfers fat-soluble toxins to water soluble toxins enabling them to be flushed out of the body.

A good way to test for Leaky Gut is if you detect constant digestive problems such as gas, bloating, constipation and other food allergies. It’s this sensitivity to foods that is the sign of a problem.

Hepatiben - Liver Detox
Leaky Gut Repair


Irritable Bowel Syndrome (IBS)

Irritable Bowel Syndrome (IBS)


There are a few typical symptoms indicating IBS, which range from abdominal pain, cramping, diarrhea, constipation and gas to nausea.1 While IBS doesn’t always lead to Leaky Gut, those suffering from NAFLDor a fatty liver are often found to have IBS.

“IBS is a common condition effecting about 25% of
Americans on a daily basis and up to 70% periodically.”

IBS is not inflammatory bowel disease (IBD) or Crone’s disease. Though Doctors are not sure of all its causes most agree that it can be triggered by; chronic stress, a low fiber diet, caffeine, alcohol, dairy, artificial sweeteners, prescription drugs, intestinal flora imbalance or a recent infection. 2

Stress and diet appear to be the main drivers. Our brains are directly connected to nerve endings in the highly vascularized intestinal tract. Signals from the brain are sent to the gut during stressful periods. This is often described by those afflicted as having a pit in the stomach or a gut feeling. This refers to the secretion of a cortisol stress hormone, and epinephrine or norepinephrine. 3

Diet certainly plays a role and to understand it we need to discuss the American diet, which has changed significantly over the past fifty plus years. Americans now consume more of the following; sugar, caffeine, harmful fats, antibiotics, preservatives, pesticides, GMOs, and hormones. These are all considered toxins to your body –especially sugar.

In fact, sugar is the major reason for the build-up of candida; known to displace good bacteria. Why are we discussing the digestive tract? What does that have to do with obesity? Everything!

The digestive tract has a very complex function as it simultaneously does two operations:

  1. Creates specific enzymes to breakdown digested food into smaller particles absorbed by the body.
  2. Selectively allows those nutrients to pass withough alonging harmful invaders; viruses, bacteria, and toxins to come along with them.

Our digestive tract is not alone in this work; it has between 3-5 lbs of bacteria in the gut to help. It’s the new American diet that’s currently accelerating the rapid growth of harmful bacteria.

Leaky Gut

When the increase in harmful bacteria and yeast (candida) within the intestine reaches a tipping point, the intestinal wall is breached. This breach allows food particles to pass through the intestine wall and the immune system becomes overwhelmed. The liver, which receives 70% of its blood flow from the intestine, is charged with detoxify the blood. If the necessary chemicals (i.e. Glutathione, NAC, Tocotrienols) are in short supply the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body. These fat cells are stored in the liver and elsewhere throughout the body. 4

The best way to counter this cycle is finding ways to alleviate stress by changing your diet and supplementing it with probiotics and strong liver antioxidants.


Why Did I Gain Back This Weight?

Obesity: Why Did I Gain Back This Weight?


Have you wondered why everyone that goes on a diet shortly thereafter gains the weight back—or why people have given up on weight loss pills? The underlining cause is the same, but the problem hasn’t been addressed.

It’s is no coincidence that states with higher poverty and diets rich in processed foods and harmful fats report the highest incidence in weight gains.


Obesity is an epidemic in the United States that affects more than 30% of Americans in Southern States while increasing to 25% in most other areas of the country, costing an estimated $147 Billion each year.

The Real Cause

Typical food consumption in America is high in the following combinations; sugar, caffeine, harmful fats, antibiotics, preservatives, pesticides, GMOs and hormones. These are all considered toxins in your body, especially the sugar.

In fact, sugar is the major reason for the build-up of candida, which displaces the good bacteria. Why are we discussing the digestive tract? What does that have to do with obesity? Everything!

The digestive tract has a very complex function for it must simultaneously do two operations:

  1. Create specific enzymes to breakdown directed food into smaller particles used in the body.
  2. Selectively allow nutrients through without passing the harmful invaders; virus, bacteria and toxins.

Our digestive tract is not alone in this work; it has between 3-5 pounds of bacteria in the gut to help. At present, however, our new American diet promotes rapid growth of harmful bacteria.

Leaky Gut

When the increase in harmful bacteria and yeast (candida) within the intestine reaches a tipping point, the intestinal wall is breached. This breach allows food particles to pass through the intestine wall and the immune system becomes overwhelmed. The liver, which receives 70% of its blood flow from the intestine, is charged with detoxifying the blood. If the necessary chemicals (i.e. Glutathione, NAC, Tocotrienols) are in short supply the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body. These fat cells are stored in the liver and elsewhere throughout the body.

Why Your Diet Doesn’t Work

Weight loss pills are mostly composed of diuretics. There will be terrific results in the short term because the body is composed mainly of water. Starving the body of water puts a terrible burden on the kidneys but doesn’t address the fat cell build-up. As soon as this diet ends water equilibrium produces weight gain and the kidneys have paid the price. Not al weight loss pills are diuretics however, and there are even a few that can be an important resource for weight loss.

Other more enlightened diets will solve most of the harmful eating habits especially raw food diets by reducing sugar, carbs, caffeine, and so on. While this reduces energy consumption in the immune system and toxins, it also initiates the engine to breakdown the old fat cells it stored. Without proper supplements that support the liver, liberated toxins circulate through the body and shuttle back into fat cells. Weight returns and these free-floating toxins have done damage to body tissues.

This is not to diminish the contribution family genetics has on this process or the emotional triggers people have regarding over-eating. Those factors have always existed, but what is significantly different is the massive increase in toxins released into the environment over the last fifty years that contributed to today’s declining health in the population.

What Works

  1. Following a raw diet will reduce the energy the body dedicates to breaking down food that’s then redirected to fat metabolism.
  2. Allowing the body’s system 12 hours per day of not eating to repair itself.
  3. Eliminating sugars, carbs, caffeine, and alcohol and adding organic foods.
  4. Drinking lots of water.
  5. Supplementing the diet with protective liver ingredients, probiotics and a biofilm dissolver like Monolaurin.

Liver Supplements

Nature provides us with the solution. Studies show that Silybin (an active compound in milk thistle) SAMe, Vitamin E (specifically highly concentrated tocotrienols,) NAC, Phosphatidylcholine and Glutathione work well when regularly applied. The success of these natural ingredients relies on rapid replenishment of Glutathione, a critically important liver antioxidant.

Extracts from milk thistle have a long history of protecting the liver. Modern scientific research has rediscovered the benefits of this herbal remedy. One very effective combination of silymarin, Vitamin E and Phosphatidylcholine improves insulin sensitivity, while reversing damaged liver cells, reducing oxidative stress, and improving Glutathione levels in the liver.

N-acetyl cysteine (NAC) is a sulfur-rich compound used primarily to neutralize the damaging effects of aspirin on the liver. It rapidly restores Glutathione. A recent animal study finds it prevents NAFLD in a liver disease diet.

Similarly, SAMe had been found to increase Glutathione levels in humans with Non-Alcohol Fatty Liver Disease.

Very few if any products on the market today contain all these ingredients and they are very expensive when purchased individually. To address this Liver Medic™ formulated Hepatiben™ to make fighting this battle easier, more effective and less expensive than the alternatives.

While we have discussed the mechanism and treatment for the liver, we can’t ignore the source of the problem. A healthy diet that promotes a healthy gut is critically important to ensuring that fatty liver disease does not return.

Often missed in efforts to restore healthy flora is the removal of biofilm, which is a frequent obstacle in improving gut health. Serrapeptase is nature’s most powerful weapon in this fight. Our enteric-coated Serrapeptase breaks apart biofilm to remove viruses, parasites and other harmful organisms. In combination with Candida Complex, is a great way to remove the bad actors and get healthy again.


References

  1. https://gis.cdc.gov/grasp/diabetes/DiabetesAtlas.html
  2. http://obesity.bodyecology.com/leaky-gut
  3. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. Journal of Nutrition. 2009 Jan;139(1):63-8.
  4. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. Journal of Biological Chemistry. 2010 Jun 11;285(24):18528
  5. Loguercio C, Federico A, Trappoliere M, et al. The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a pilot study. Digestive Disease & Sciences. 2007 Sep;52(9):2387-95.
  6. Serviddio G, Bellanti F, Giudetti AM, et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. Journal of Pharmacology and Experimental Therapeutics. 2010 Mar;332(3):922-32.
  7. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. Journal of Nutrition. 2008 Oct;138(10):1872-9.
  8. Vendemiale G, Altomare E, Trizio T, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scandanavian Journal of Gastroenterology. 1989 May;24(4):407-15.

Non Alcoholic Fatty Liver Disease

Non Alcoholic Fatty Liver Disease – NAFLD


Non alcoholic Fatty Liver Disease (NAFLD) affects about one-third of Americans and most people are completely unaware and undiagnosed. Symptoms of NAFLD range from diabetes, obesity, Irritable Bowel Syndrome ( IBS) to chronic fatigue, food allergies and metabolic syndrome.

Disease Progression

Left untreated NAFLD morphs into more advanced stages like non-alcoholic steatohepatitis, fibrosis, cirrhosis, and liver failure. Adults are not alone; shockingly 10% of children in America are also effected .1 Statistics for people living with advanced liver diseases are grim.

Mechanism

NAFLD is the accumulation of fat cells in the liver, interrupting normal liver function in the absence of alcohol consumption. Although this kind of liver damage is common among alcohol consumers, this disease now effects those with diets high in processed foods with similar results. This typically causes inflammation and in more severe cases tissue death and fibrosis.

Excess fat cells accumulate in the liver beginning a destructive cycle and the liver becomes less efficient, leading to a build-up of toxins including fatty acids and insulin. The result is insulin resistance in type II diabetes. Tests that confirm the overload of fatty acids known as lipotoxicity can lead to metabolic syndrome and NAFLD.

In the past, the scientific community had been confused about the causes of NAFLD; now recent studies point to a leaking gut with an influx of free floating food particles and toxins in the body as a culprit. Leaky Gut is an improper balance of bacteria in the body leading to intestinal wall breach with a destructive cascade of health problems.

When the liver can no longer detoxify the influx of foreign substances they are swept into fat cells to be broken down later. While the obesity it produces can be observed externally, dangerous conditions compromise the health of the body’s organs internally.

There are two main systems designed to remove these invaders–the immune system and the liver. As Americans consume increasing amounts of sugar, caffeine, antibiotics, GMOs, pesticides, and hormones these two systems become overwhelmed. A further discussion on how the liver works including the two main phases is located here.

What Doesn’t Work

The pharmaceutical industry has been working on cures for NAFLD and related diseases with little success. Thus far Metformin has had the only successful attempt by the industry. Metformin has limited effectiveness as it is an insulin-sensitizing drug that only addresses part of the issue, though it represents a marked improvement over preceding pharmaceutical alternatives.

What Works

Fortunately, nature provides us with the solution. Studies demonstrate that Silybin (active compound in milk thistle), SAMe, Vitamin E (specifically, highly concentrated tocotrienols), NAC, Phosphatidylcholine and Glutathione work best with repeatable results. The success of these natural ingredients relies on rapid replenishment of Glutathione, a critically important liver antioxidant. 2, 3

Extracts from milk thistle have a long history in liver protection. Its rediscovery by science offers a renewed appreciation for its properties and health benefits. One very effective combination of silymarin, Vitamin E and Phosphatidylcholine, is an improvement in insulin sensitivity while reversing damaged liver cells reducing oxidative stress and improving Glutathione levels in the liver. 4, 5

N-acetyl cysteine (NAC) is a sulfur-rich compound used primarily to neutralize the damaging effects of aspirin on the liver. It rapidly restores Glutathione. A recent animal study finds it prevents NAFLD in a liver disease diet 6. Similarly, SAMe had been found to increase Glutathione levels in humans with Fatty Liver Disease. 7

Very few, if any products on the market contain all these ingredients and they are very expensive when purchased individually. To address this Liver Medic formulated Hepatiben to make fighting this battle easier, more effective and less expensive than the alternatives.

While we have discussed the mechanism and treatment for the liver, we can’t ignore the source of the problem. A healthy diet promotes a healthy gut and is critically important in ensuring that fatty liver disease does not return.

Often missed in efforts to restore healthy flora is the removal of biofilm, which is a frequent obstacle in improving gut health. Serrapeptase is nature’s most powerful weapon in this fight. Our enteric-coated Serrapeptase breaks apart biofilm to remove viruses, parasites and other harmful organisms. In combination with Candida Complex, is a great way to remove the bad actors and get healthy again.


References

  1. Polyzos SA, Kountouras J, Zavos C, Tsiaousi E. The role of adiponectin in the pathogenesis and treatment of nonalcoholic fatty liver disease. Diabetes Obes Metab. 2010 May;12(5):365-83.
  2. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J Nutr. 2009 Jan;139(1):63-8.
  3. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem. 2010 Jun 11;285(24):18528-
  4. Loguercio C, Federico A, Trappoliere M, et al. The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci. 2007 Sep;52(9):2387-95.
  5. Serviddio G, Bellanti F, Giudetti AM, et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. J Pharmacol Exp Ther. 2010 Mar;332(3):922-32.
  6. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J Nutr. 2008 Oct;138(10):1872-9.
  7.  Vendemiale G, Altomare E, Trizio T, et al. Effects of ora oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989 May;24(4):407-15.

GMO Safe List

GMO Safe List


We all know the “hidden” and not so hidden dangers of Genetically Modified Organisms (GMOs). Some scientists would have you believe that we have been altering organisms for millennium, which is true. But we have never before been splicing DNA with the help of virulent bacteria and virus to insert pesticides, which are causing massive tumors in lab mice.

This is hardly the same category of scientific engineering as Mendel’s pea plant experiments many generations ago.

How Are We to Know What Foods To Avoid?

This can be a real challenge as there has been a race by processed food manufacturers to incorporate GMO foods quickly before regulation can be introduced.

Thankfully, our friends at Nation of Change have put together a GMO free food list, which we will email to you. Please send your request to cs@livermedic.com and we will provide this valuable information.

Silybin vs Milk Thistle

Silybin vs Milk Thistle:
Far Superior Bioavailability for Liver Disorders


Milk thistle has been in use for well over 2,000 years for liver disorders. Ancient civilizations noticed the health benefits from early on and science now indicates milk thistle’s benefits come from its ability to protect against cellular damage particularly in the liver, gallbladder and bile ducts. For example, ancient Romans used milk thistle to treat most any toxin in the body, even snakebites. However, it was primarily used for common liver ailments.

In Germany, the Health Department commissioned studies and concluded that milk thistle should be used in liver damage treatment even as severe as cirrhosis due to its safety and efficacy.

The active medical ingredient in milk thistle is silymarin, found in the milk thistle seed. Silymarin is composed of 6 compounds and Silybin is the one identified in bestowing its health benefits.


Comparing Bioavailability

Its important to note that the comparative bioavailability of silybin over milk thistle is higher. Most studies show the absorption between the two is approximately 10:1. Mathematically stated, this requires 1000 mg of milk thistle to equal the health benefits found in that of 100 mg of silybin.


Choline's Important Role:

Many are not aware the ingredient choline further increases silybin's bioavailability. A common form of choline in supplementation is phosphatidylcholine. When choosing a supplement to treat fatty liver or other liver ailments, this should be a consideration.1

There are studies that prove increased absorption of the silybin phosphatidylcholine complex at approximately 7-8 times that without phosphatidylcholine. Any supplements taken to treat the liver, gallbladder and or bile ducts must have these two ingredients without exception to most effective: silybin and phosphatidylcholine.2

The Way in Which Silybin Works is as Follows:

  1. Increasing the strength of cell walls, making it more difficult for toxins to cross into the cell.
  2. Promoting the breakdown of toxins especially in the liver (Phase II Conjugation).
  3. Acting as an anti-oxidant, blocking cell wall damage from free radicals.

Laboratory experiments have show silybin has possible cancer benefits as well, although Liver Medic does not endorse using silybin in place of cancer treatments. Independant studies have shown silybin decreases the toxicity of treatment and may slow the growth of certain cancers, while promoting healthy cell.3



HEPATIBEN - Maximum Liver Cleanse

Ingredients:

Silybin
Phosphatidylcholine
MSM
Turmeric (95% Curcuminoids)

NAC (N-Acetyl Cysteine)
Berberine HCl
L-Glutathione
ALA