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Metabolic Syndrome

METABOLIC SYNDROME


Having Metabolic Syndrome doubles the risk for heart disease and multiples the risk of diabetes by five.It is not a disease itself but describes a host of related risk factors (high blood pressure, high blood sugar, unhealthy cholesterol levels, obesity and insulin resistance) all with a common cause originally coined 20 years ago effecting 47 million Americans affected.

Notice that Metabolic Syndrome closely mirrors the symptoms found in those suffering from NAFLD . NAFLD can be thought of as the liver’s state of Metabolic Syndrome. Following the progression of Metabolic Syndrome and NAFLD, one has a hard time disputing the causal relationship.

Cause & Effect

We need to begin with the American diet, which has changed significantly over the past fifty plus years. Americans now consume far too much of the following:

“sugar, caffeine, harmful fats, antibiotics,
preservatives, pesticides, GMOs and hormones.”

These are all considered toxins to your body, especially sugar. In fact, the sugar is the major reason for the build-up of candida, which displaces the good bacteria. Why are we discussing the digestive tract? What does that have to do with obesity? Everything.

The digestive tract has a very complex function; it simultaneously does two operations.

  1. Create specific enzymes to breakdown digested food into smaller particles used in the body.
  2. Selectively allow nutrients through without passing the harmful invaders; virus, bacteria and toxins.

Our digestive tract is not alone in this work; it has between 3-5 lbs of bacteria in the gut to help. However, our new American diet promotes rapid growth of harmful bacteria.

Leaky Gut

When an increase in harmful bacteria and yeast (candida) within the intestine reaches a tipping point, the intestinal wall is breached. This breach allows food particles to pass through the intestine wall and the immune system becomes overwhelmed. The liver, which receives 70% of its blood flow from the intestine, is charged with detoxify the blood. If the necessary chemicals (i.e. Glutathione, NAC, Tocotrienols) are in short supply the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body.These fat cells are stored in the liver and elsewhere throughout the body. 2

“The liver receives 70% of its
blood flow from the intestine”

This fat cell build-up stored in the liver and elsewhere around the body, is producing an obesity epidemic.

Excess accumulation of fat cells in the liver begins a destructive cycle where the liver becomes less efficient, leading to a build-up of toxins including fatty acids and insulin. This spike in oxidative stress and unprocessed insulin leads to insulin resistance in type II diabetes. Tests confirm the overload of fatty acids called lipotoxicity. This cascade explains the risk factors relating to Metabolic Syndrome.

What Works

Fortunately nature provides us with the solution. Studies have shown Silybin (an active compound in milk thistle), SAMe, Vitamin E (specifically highly concentrated tocotrienols), NAC, Phosphatidylcholine and Glutathione to work best with repeatable results. The success of these natural ingredients relies on rapid replenishment of Glutathione, a critically important liver antioxidant.

Extracts from milk thistle have a long history of being used for liver protection. We are just now starting to rediscover this through scientific discovery. One very effective combination including; Silymarin, Vitamin E and Phosphatidylcholine improves insulin sensitivity, while reversing liver cell damage. This is accomplished by reducing oxidative stress and improving Glutathione levels in the liver.

N-acetyl cysteine (NAC) is a sulfur-rich compound used primarily to neutralize the damaging effects of aspirin on the liver. It rapidly restores Glutathione. A recent animal study showed it to prevent NAFLD in a liver disease diet. Similarly, SAMe had been found to increase Glutathione levels in humans with Non-Alcohol Fatty Liver Disease.

Very few if any products on the market today contain all these ingredients and they are very expensive when purchased individually. To address this Liver Medic formulated a more complete liver detox supplement to make fighting this battle easier, more effective and less expensive than the alternatives.

While we have discussed the mechanism and treatment for the liver, we can’t ignore the source of the problem. A healthy diet promotes a healthy gut, this is critically important to ensuring that fatty liver disease does not return.

Often missed in attempts to return to a healthy gut balance is the removal of candida and biofilm, a major obstacle in improving gut health. We have addressed this with other gut support products specifically formulated for candida removal and biofilm removal. Take these along with power liver supplements and the body will begin to regulate itself without the toxic interference.

The proper use of these products not only reverses liver damage but also protects against future damage.*


References

  1. http://www.webmd.com/heart/metabolic-syndrome/metabolic-syndrome-what-is-it
  2. http://obesity.bodyecology.com/leaky-gu
  3. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. Journal of Nutrition. 2009 Jan;139(1):63-
  4. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biological Chemistry. 2010 Jun 11;285(24):18528-
  5. Loguercio C, Federico A, Trappoliere M, et al. The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a pilot study. Digestive Disease & Sciences. 2007 Sep;52(9):2387-95.
  6. Serviddio G, Bellanti F, Giudetti AM, et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. Journal of Pharmacology and Experimental Therapeutics. 2010 Mar;332(3):922-32.
  7. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. Journal of Nutrition. 2008 Oct;138(10):1872-9.
  8. Vendemiale G, Altomare E, Trizio T, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand Journal of Gastroenterology. 1989 May;24(4):407-15.
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Why Did I Gain Back This Weight?

Obesity: Why Did I Gain Back This Weight?


Have you wondered why everyone that goes on a diet shortly thereafter gains the weight back—or why people have given up on weight loss pills? The underlining cause is the same, but the problem hasn’t been addressed.

It’s is no coincidence that states with higher poverty and diets rich in processed foods and harmful fats report the highest incidence in weight gains.


Obesity is an epidemic in the United States that affects more than 30% of Americans in Southern States while increasing to 25% in most other areas of the country, costing an estimated $147 Billion each year.

The Real Cause

Typical food consumption in America is high in the following combinations; sugar, caffeine, harmful fats, antibiotics, preservatives, pesticides, GMOs and hormones. These are all considered toxins in your body, especially the sugar.

In fact, sugar is the major reason for the build-up of candida, which displaces the good bacteria. Why are we discussing the digestive tract? What does that have to do with obesity? Everything!

The digestive tract has a very complex function for it must simultaneously do two operations:

  1. Create specific enzymes to breakdown directed food into smaller particles used in the body.
  2. Selectively allow nutrients through without passing the harmful invaders; virus, bacteria and toxins.

Our digestive tract is not alone in this work; it has between 3-5 pounds of bacteria in the gut to help. At present, however, our new American diet promotes rapid growth of harmful bacteria.

Leaky Gut

When the increase in harmful bacteria and yeast (candida) within the intestine reaches a tipping point, the intestinal wall is breached. This breach allows food particles to pass through the intestine wall and the immune system becomes overwhelmed. The liver, which receives 70% of its blood flow from the intestine, is charged with detoxifying the blood. If the necessary chemicals (i.e. Glutathione, NAC, Tocotrienols) are in short supply the liver simply shuttles the toxins into fat cells to keep them from invading the rest of the body. These fat cells are stored in the liver and elsewhere throughout the body.

Why Your Diet Doesn’t Work

Weight loss pills are mostly composed of diuretics. There will be terrific results in the short term because the body is composed mainly of water. Starving the body of water puts a terrible burden on the kidneys but doesn’t address the fat cell build-up. As soon as this diet ends water equilibrium produces weight gain and the kidneys have paid the price. Not al weight loss pills are diuretics however, and there are even a few that can be an important resource for weight loss.

Other more enlightened diets will solve most of the harmful eating habits especially raw food diets by reducing sugar, carbs, caffeine, and so on. While this reduces energy consumption in the immune system and toxins, it also initiates the engine to breakdown the old fat cells it stored. Without proper supplements that support the liver, liberated toxins circulate through the body and shuttle back into fat cells. Weight returns and these free-floating toxins have done damage to body tissues.

This is not to diminish the contribution family genetics has on this process or the emotional triggers people have regarding over-eating. Those factors have always existed, but what is significantly different is the massive increase in toxins released into the environment over the last fifty years that contributed to today’s declining health in the population.

What Works

  1. Following a raw diet will reduce the energy the body dedicates to breaking down food that’s then redirected to fat metabolism.
  2. Allowing the body’s system 12 hours per day of not eating to repair itself.
  3. Eliminating sugars, carbs, caffeine, and alcohol and adding organic foods.
  4. Drinking lots of water.
  5. Supplementing the diet with protective liver ingredients, probiotics and a biofilm dissolver like Monolaurin.

Liver Supplements

Nature provides us with the solution. Studies show that Silybin (an active compound in milk thistle) SAMe, Vitamin E (specifically highly concentrated tocotrienols,) NAC, Phosphatidylcholine and Glutathione work well when regularly applied. The success of these natural ingredients relies on rapid replenishment of Glutathione, a critically important liver antioxidant.

Extracts from milk thistle have a long history of protecting the liver. Modern scientific research has rediscovered the benefits of this herbal remedy. One very effective combination of silymarin, Vitamin E and Phosphatidylcholine improves insulin sensitivity, while reversing damaged liver cells, reducing oxidative stress, and improving Glutathione levels in the liver.

N-acetyl cysteine (NAC) is a sulfur-rich compound used primarily to neutralize the damaging effects of aspirin on the liver. It rapidly restores Glutathione. A recent animal study finds it prevents NAFLD in a liver disease diet.

Similarly, SAMe had been found to increase Glutathione levels in humans with Non-Alcohol Fatty Liver Disease.

Very few if any products on the market today contain all these ingredients and they are very expensive when purchased individually. To address this Liver Medic™ formulated Hepatiben™ to make fighting this battle easier, more effective and less expensive than the alternatives.

While we have discussed the mechanism and treatment for the liver, we can’t ignore the source of the problem. A healthy diet that promotes a healthy gut is critically important to ensuring that fatty liver disease does not return.

Often missed in efforts to restore healthy flora is the removal of biofilm, which is a frequent obstacle in improving gut health. Serrapeptase is nature’s most powerful weapon in this fight. Our enteric-coated Serrapeptase breaks apart biofilm to remove viruses, parasites and other harmful organisms. In combination with Candida Complex, is a great way to remove the bad actors and get healthy again.


References

  1. https://gis.cdc.gov/grasp/diabetes/DiabetesAtlas.html
  2. http://obesity.bodyecology.com/leaky-gut
  3. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. Journal of Nutrition. 2009 Jan;139(1):63-8.
  4. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. Journal of Biological Chemistry. 2010 Jun 11;285(24):18528
  5. Loguercio C, Federico A, Trappoliere M, et al. The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a pilot study. Digestive Disease & Sciences. 2007 Sep;52(9):2387-95.
  6. Serviddio G, Bellanti F, Giudetti AM, et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. Journal of Pharmacology and Experimental Therapeutics. 2010 Mar;332(3):922-32.
  7. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. Journal of Nutrition. 2008 Oct;138(10):1872-9.
  8. Vendemiale G, Altomare E, Trizio T, et al. Effects of oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scandanavian Journal of Gastroenterology. 1989 May;24(4):407-15.

Type II Diabetes

How To Reverse Type II Diabetes


The trend for adults with diagnosed Type II Diabetes in America is staggering. In just the past thirty years it has ballooned three fold from 493,000 to 1.8 million new cases each year.

There are age, gender and race differences highlighting genetic influences, but all groups are trending in the wrong direction. Those with family members with diabetes have a dramatically greater likelihood of becoming diabetic themselves. We are also witnessing massive increases in pediatric Type II Diabetes.2

Type II Diabetes Background

Unlike those with Type I Diabetes, Type II Diabetics produce insulin. Type II Diabetes glucose spikes occur when the pancreas doesn’t produce enough insulin or where there is a lack of insulin sensitivity. The lack of insulin sensitivity is known as insulin resistance. Insulin resistance produces excess glucose that circulates throughout the body. It leads to damaged nerves and small blood vessels in the eyes, kidneys, and heart. The body’s health is further compromised when it then becomes dehydrated.

"Type II is the most common form of diabetes, affecting 90-95% of the 26 million American Diabetics."3

Cause & Effect

There is some debate in the scientific community about the causes of this increase. Most nutritionists would agree that diet is mostly, if not entirely to blame. It is also influenced by a lack of physical activity.

There are two main drivers of this new insulin resistance:

  1. Increased oxidative stress. 4
  2. Sugars with high glycemic indexes, especially high fructose corn syrup (HFCS). 5

The body’s high oxidative stress environment is explained in our NAFLD post. These factors are interrelated as toxins present in the body compromise the intestinal wall overwhelming the liver and immune system resulting in oxidative stress.

This type of oxidative stress disrupts sensitivity to insulin in the body. The terms to describe this condition are known as Metabolic Syndrome 6 or Diabesity. 7 This is in addition to the chronic inflammation oxidative stress causes and leads to a multitude of other health issues.

Metabolic Syndrome is defined by common pathologies: obesity, insulin resistance, dyslipidemia, and hypertension. Recent studies have also concluded that high fructose corn syrup has a similar outcome in reducing insulin sensitivity. The use for HFCS has increased 1000% in the past 40 years.8

Recently the food industry introduced agave a ‘natural’ as an alternative to sugar. Unfortunately, agave has an even higher glycemic index and might even accelerate this process. In response to this the American Diabetic Association has recommended that agave be limited in diabetic diets.9


Non Alcoholic Fatty Liver Disease

Non Alcoholic Fatty Liver Disease – NAFLD


Non alcoholic Fatty Liver Disease (NAFLD) affects about one-third of Americans and most people are completely unaware and undiagnosed. Symptoms of NAFLD range from diabetes, obesity, Irritable Bowel Syndrome ( IBS) to chronic fatigue, food allergies and metabolic syndrome.

Disease Progression

Left untreated NAFLD morphs into more advanced stages like non-alcoholic steatohepatitis, fibrosis, cirrhosis, and liver failure. Adults are not alone; shockingly 10% of children in America are also effected .1 Statistics for people living with advanced liver diseases are grim.

Mechanism

NAFLD is the accumulation of fat cells in the liver, interrupting normal liver function in the absence of alcohol consumption. Although this kind of liver damage is common among alcohol consumers, this disease now effects those with diets high in processed foods with similar results. This typically causes inflammation and in more severe cases tissue death and fibrosis.

Excess fat cells accumulate in the liver beginning a destructive cycle and the liver becomes less efficient, leading to a build-up of toxins including fatty acids and insulin. The result is insulin resistance in type II diabetes. Tests that confirm the overload of fatty acids known as lipotoxicity can lead to metabolic syndrome and NAFLD.

In the past, the scientific community had been confused about the causes of NAFLD; now recent studies point to a leaking gut with an influx of free floating food particles and toxins in the body as a culprit. Leaky Gut is an improper balance of bacteria in the body leading to intestinal wall breach with a destructive cascade of health problems.

When the liver can no longer detoxify the influx of foreign substances they are swept into fat cells to be broken down later. While the obesity it produces can be observed externally, dangerous conditions compromise the health of the body’s organs internally.

There are two main systems designed to remove these invaders–the immune system and the liver. As Americans consume increasing amounts of sugar, caffeine, antibiotics, GMOs, pesticides, and hormones these two systems become overwhelmed. A further discussion on how the liver works including the two main phases is located here.

What Doesn’t Work

The pharmaceutical industry has been working on cures for NAFLD and related diseases with little success. Thus far Metformin has had the only successful attempt by the industry. Metformin has limited effectiveness as it is an insulin-sensitizing drug that only addresses part of the issue, though it represents a marked improvement over preceding pharmaceutical alternatives.

What Works

Fortunately, nature provides us with the solution. Studies demonstrate that Silybin (active compound in milk thistle), SAMe, Vitamin E (specifically, highly concentrated tocotrienols), NAC, Phosphatidylcholine and Glutathione work best with repeatable results. The success of these natural ingredients relies on rapid replenishment of Glutathione, a critically important liver antioxidant. 2, 3

Extracts from milk thistle have a long history in liver protection. Its rediscovery by science offers a renewed appreciation for its properties and health benefits. One very effective combination of silymarin, Vitamin E and Phosphatidylcholine, is an improvement in insulin sensitivity while reversing damaged liver cells reducing oxidative stress and improving Glutathione levels in the liver. 4, 5

N-acetyl cysteine (NAC) is a sulfur-rich compound used primarily to neutralize the damaging effects of aspirin on the liver. It rapidly restores Glutathione. A recent animal study finds it prevents NAFLD in a liver disease diet 6. Similarly, SAMe had been found to increase Glutathione levels in humans with Fatty Liver Disease. 7

Very few, if any products on the market contain all these ingredients and they are very expensive when purchased individually. To address this Liver Medic formulated Hepatiben to make fighting this battle easier, more effective and less expensive than the alternatives.

While we have discussed the mechanism and treatment for the liver, we can’t ignore the source of the problem. A healthy diet promotes a healthy gut and is critically important in ensuring that fatty liver disease does not return.

Often missed in efforts to restore healthy flora is the removal of biofilm, which is a frequent obstacle in improving gut health. Serrapeptase is nature’s most powerful weapon in this fight. Our enteric-coated Serrapeptase breaks apart biofilm to remove viruses, parasites and other harmful organisms. In combination with Candida Complex, is a great way to remove the bad actors and get healthy again.


References

  1. Polyzos SA, Kountouras J, Zavos C, Tsiaousi E. The role of adiponectin in the pathogenesis and treatment of nonalcoholic fatty liver disease. Diabetes Obes Metab. 2010 May;12(5):365-83.
  2. Kwon do Y, Jung YS, Kim SJ, Park HK, Park JH, Kim YC. Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J Nutr. 2009 Jan;139(1):63-8.
  3. Caballero F, Fernandez A, Matias N, et al. Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem. 2010 Jun 11;285(24):18528-
  4. Loguercio C, Federico A, Trappoliere M, et al. The effect of a silybin-vitamin E-phospholipid complex on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci. 2007 Sep;52(9):2387-95.
  5. Serviddio G, Bellanti F, Giudetti AM, et al. A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis. J Pharmacol Exp Ther. 2010 Mar;332(3):922-32.
  6. Baumgardner JN, Shankar K, Hennings L, Albano E, Badger TM, Ronis MJ. N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis. J Nutr. 2008 Oct;138(10):1872-9.
  7.  Vendemiale G, Altomare E, Trizio T, et al. Effects of ora oral S-adenosyl-L-methionine on hepatic glutathione in patients with liver disease. Scand J Gastroenterol. 1989 May;24(4):407-15.

GMO Safe List

GMO Safe List


We all know the “hidden” and not so hidden dangers of Genetically Modified Organisms (GMOs). Some scientists would have you believe that we have been altering organisms for millennium, which is true. But we have never before been splicing DNA with the help of virulent bacteria and virus to insert pesticides, which are causing massive tumors in lab mice.

This is hardly the same category of scientific engineering as Mendel’s pea plant experiments many generations ago.

How Are We to Know What Foods To Avoid?

This can be a real challenge as there has been a race by processed food manufacturers to incorporate GMO foods quickly before regulation can be introduced.

Thankfully, our friends at Nation of Change have put together a GMO free food list, which we will email to you. Please send your request to cs@livermedic.com and we will provide this valuable information.

Metabolic Syndrome: Compelling Research & Connections

Metabolic Syndrome:
Compelling Research & Connections


Almost a third of Americans have Fatty Liver Disease although most people aren’t aware they have it. A recent report by “Trust for America’s Health” indicates that a third of Americans are also obese. While growth of these diseases is not surprising to many, the causes are becoming much better understood.

Dr. Robynne Chutkan, Medical Director at Digestive Center for Women, finds that leaky gut is at the center of an epidemic. Leaky gut is the widening of junctions allowing viruses, whole food, bacteria and other toxins to pass through the intestinal wall. Once in the body, the immune system is triggered and over time this produces chronic inflammation.

“Chronic Inflammation is but one condition of Metabolic Syndrome that includes Type II Diabetes, high blood pressure and other ailments.”

When the immune system and the liver become overwhelmed, fat cells are manufactured to imprison these toxic invaders leading to Fatty Liver Disease.

Dr. Chutkan and others agree that sugar, antibiotics, pesticides, GMOs and chronic stress contribute to this rise in leaky gut. . A strong case can be made that an increase in fructose corn syrup coupled with candida increases development of Metabolic Syndrome.

“Sugar is a poison like ethanol"
Dr. Robert H. Lustig, Nueroendocrinologist University of California 

This is especially true of fructose because fructose doesn’t trigger insulin or suppress appetite like other sugars. In the past twenty-five years Americans average 25 pounds more in body weight, consuming 63 pounds of fructose every year. This is seven times the amount Americans consumed 100 years ago.

Our fiber intake also decreased from 200 to 300 grams per day to 20 grams. Fiber is necessary to slow the absorption of fructose toxicity, which the liver must then neutralize. The key to preserving one’s health is avoiding diets high in carbohydrates that include sugar and processed foods. Healthy alternatives must include an increase in fiber and protein to maintain proper gut and liver health, which will also prevent the growth of candida.

“Candida can be controlled through supplements, but once the path to recovery is chosen and candida die off, they release over 75 toxins that must be processed by the liver.”

So liver supplements must also accompany this so the individual doesn’t feel tired and sluggish by toxin overload damaging the body.

US Most Obese and It’s Not Even Close

Winning! US Most Obese and It’s Not Even Close


According to the latest international obesity study from the Organization For Economic Co-operation and Development (OECD), America is by far the fattest nation in the world with just over 38% of the adult population considered ‘obese.’

Here are some stats from the OECD’s latest study courtesy of the Washington Examiner:

  • In 2015, an estimated 603.7 million adults and 107.7 million children worldwide were obese. That represents about 12 percent of all adults and 5 percent of all children.

  • The prevalence of obesity doubled in 73 countries between 1980 and 2015and continuously increased in most of the other countries.

  • China and India had the highest number of obese children. China and the U.S. had the highest number of obese adults.

  • Excess body weight accounted for about 4 million deaths or 7.1 percent of all deaths in 2015.

  • Almost 70 percent of deaths related to a high BMI were due to cardiovascular disease.

  • The study finds evidence that having a high BMI causes leukemia and several types of cancer, including cancers of the esophagus, liver, breast, uterus, ovary, kidney and thyroid.